The Cafe Hotel Appenzell is located in the peaceful area of Hauptgasse. It is near cycling tracks and hiking trails. The city center of Appenzell, the train station, and the bus stop are also within ten minutes from the hotel.

Each room in the Cafe Hotel Appenzell has a private bathroom and a small lounge area. Other room amenities include daily newspapers, desks, and hairdryers. Guests can ask for additional items.

The Cafe Hotel Appenzell offers tour assistance, a bicycle rental center, amenities for disabled guests. It also provides an on-site restaurant, laundry and dry cleaning service, as well as room service.